62 research outputs found

    La presencia del evolucionismo en las Ciencias Sociales y en particular en la Psicología

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    En el presente trabajo se examina el impacto actual de Charles Darwin en el complejo campo de las ciencias sociales, prestando atención particular a la psicología actual. El método utilizado ha sido el análisis de las citas dirigidas a Darwin en las publicaciones vaciadas por el Social Sciences Citation Index. El objetivo planteado ha sido determinar el número de citas recibidas, precisar su distribución temporal, y consignar las obras más relevantes según el criterio. Además, se analiza el ámbito científico en el que muestran mayor impacto y las revistas máximas citadoras

    Performance of the Opalinus Clay under thermal loading: experimental results from Mont Terri rock laboratory (Switzerland)

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    The final publication is available at Springer via http://dx.doi.org/10.1007/s00015-016-0258-8The paper presents an overview of the behaviour of Opalinus Clay under thermal loading as observed in three in situ heating tests performed in the Mont Terri rock laboratory: HE-B, HE-D and HE-E. The three tests are summarily described; they encompass a broad range of test layouts and experimental conditions. Afterwards, the following topics are examined: determination of thermal conductivity, thermally-induced pore pressure generation and thermally-induced mechanical effects. The mechanisms underlying pore pressure generation and dissipation are discussed in detail and the relationship between rock damage and thermal loading is examined using an additional in situ test: SE-H. The paper concludes with an evaluation of the various thermo-hydro-mechanical (THM) interactions identified in the heating tests.Peer ReviewedPostprint (author's final draft

    Red de coordinación en la implementación eficaz de las asignaturas en inglés en la titulación de Arquitectura

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    Con motivo de la ampliación de oferta de docencia en inglés del grado en Arquitectura se ha generado una red de elaboración de acciones conjuntas y propuestas que promuevan la cooperación para asegurar una mayor conexión y coherencia disciplinar de las asignaturas con docencia en inglés. Durante los últimos años han ido incorporándose a la docencia de la titulación de Arquitectura diferentes asignaturas con oferta de grupos en inglés. Para el curso 2014-15 se espera que haya cerca de 10 asignaturas con docencia en inglés y consideramos fundamental la coordinación entre ellas para proporcionar una enseñanza y una formación eficaz para aspirar a generar un grupo ARA en la titulación

    COVID-19; SARS-Cov-2; COVID-19 Testing; Otolaryngology

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    The SARS CoV-2 (COVID-19) disease has caused millions of cases since the pandemic status was declared by the World Health Organization (WHO) in March 2020, changing the usual medical and surgical practices. Doctors and nurses represent a significant percentage of the general population infected. Among them, the special risk of infection in otorhinolaryngologists and head and neck surgeons (ENT) stands out, due to the proximity to the upper airway and the risk of generation of bioaerosols during procedures./nThe objective of this article is to prepare a document on safe otorhinolaryngological practice during the COVID19 pandemic, based on a compilation of the best evidence adapted to the risk of transmission, according to the combination of the results of the risk indicators established by the Ministry of Health, Consumption and Social Welfare (MSCBS). This document is the result of the collaboration of the scientific commissions and the COVID-19 committee of the SEORLCCC.La enfermedad por el SARS CoV-2 (COVID-19) ha provocado millones de casos desde que se declarase el estado de pandemia por la Organización Mundial de la Salud (OMS) en marzo de 2020, cambiando las prácticas médicas y quirúrgicas habituales. Los sanitarios representan un importante porcentaje de la población general contagiada. Entre ellos, destaca el especial riesgo de infección en otorrinolaringólogos y cirujanos de cabeza y cuello (ORL), debido a la cercanía a la vía aérea superior y al riesgo de generación de bioaerosoles durante los procedimientos./nEl objetivo de este artículo es la elaboración de un documento de práctica otorrinolaringológica segura durante la pandemia COVID19, basado en una recopilación de la mejor evidencia adaptada al riesgo de transmisión, según la combinación de los resultados de los indicadores de riesgo establecidos por el Ministerio de Sanidad, Consumo y Bienestar Social (MSCBS). El presente documento es fruto de la colaboración de las comisiones científicas y del comité COVID-19 de la SEORLCCC

    ENT practice during the COVID19 pandemic

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    Introducción: La enfermedad por el SARS CoV-2 (COVID-19) ha provocado millones de casos desde que se declarase el estado de pandemia por la Organización Mundial de la Salud (OMS) en marzo de 2020, cambiando las prácticas médicas y quirúrgicas habituales. Los sanitarios representan un importante porcentaje de la población general contagiada. Entre ellos, destaca el especial riesgo de infección en otorrinolaringólogos y cirujanos de cabeza y cuello (ORL), debido a la cercanía a la vía aérea superior y al riesgo de generación de bioaerosoles durante los procedimientos. Objetivo: El objetivo de este artículo es la elaboración de un documento de práctica otorrinolaringológica segura durante la pandemia COVID19. Método: Revisión bibliográfica. Resultados: Recopilación de la mejor evidencia adaptada al riesgo de trans misión, según la combinación de los resultados de los indicadores de riesgo establecidos por el Ministerio de Sanidad, Consumo y Bienestar Social (MSCBS). El presente documento es fruto de la colaboración de las comisiones científicas y del comité COVID-19 de la SEORLCCC.Introduction: The SARS CoV-2 (COVID-19) disease has caused millions of cases since the pandemic status was declared by the World Health Organization (WHO) in March 2020, changing the usual medical and surgical practices. Doctors and nurses represent a significant percentage of the general population infected. Among them, the special risk of infection in otorhinolaryngologists and head and neck surgeons (ENT) stands out, due to the proximity to the upper airway and the risk of generation of bioaerosols during procedures. Objective: The objective of this article is to prepare a document on safe otorhinolaryngological practice during the COVID19 pandemic. Results: Compilation of the best evidence adapted to the risk of transmission, according to the combination of the results of the risk indicators established by the Ministry of Health, Consumption and Social Welfare (MSCBS). This document is the result of the collaboration of the scientific commissions and the COVID-19 committee of the SEORLCCC

    CD44 Modulates Cell Migration and Invasion in Ewing Sarcoma Cells

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    The chimeric EWSR1::FLI1 transcription factor is the main oncogenic event in Ewing sarcoma. Recently, it has been proposed that EWSR1::FLI1 levels can fluctuate in Ewing sarcoma cells, giving rise to two cell populations. EWSR1::FLI1low cells present a migratory and invasive phenotype, while EWSR1::FLI1high cells are more proliferative. In this work, we described how the CD44 standard isoform (CD44s), a transmembrane protein involved in cell adhesion and migration, is overexpressed in the EWSR1::FLI1low phenotype. The functional characterization of CD44s (proliferation, clonogenicity, migration, and invasion ability) was performed in three doxycycline-inducible Ewing sarcoma cell models (A673, MHH-ES1, and CADO-ES1). As a result, CD44s expression reduced cell proliferation in all the cell lines tested without affecting clonogenicity. Additionally, CD44s increased cell migration in A673 and MHH-ES1, without effects in CADO-ES1. As hyaluronan is the main ligand of CD44s, its effect on migration ability was also assessed, showing that high molecular weight hyaluronic acid (HMW-HA) blocked cell migration while low molecular weight hyaluronic acid (LMW-HA) increased it. Invasion ability was correlated with CD44 expression in A673 and MHH-ES1 cell lines. CD44s, upregulated upon EWSR1::FLI1 knockdown, regulates cell migration and invasion in Ewing sarcoma cells.This project was funded by Instituto de Salud Carlos III, grant numbers PI20CIII/00020, DTS18CIII/00005, Asociación Pablo Ugarte, grant numbers TRPV205/18; Asociación Candela Riera, Asociación Todos Somos Iván & Fundación Sonrisa de Alex, grant numbers TVP333-19, TVP-1324/15; ASION, grant number TVP141/17. Enrique Fernández-Tabanera is supported by Asociación Candela Riera, Asociación Todos Somos Iván & Fundación Sonrisa de Alex, Saint T. Cervera is supported by Asociación Pablo Ugarte and Raquel M. Melero is supported by a CIBERER contract.S

    Synthesis of 2D porous crystalline materials in simulated microgravity

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    Altres ajuts: the ICN2 is funded by the CERCA programme/Generalitat de Catalunya. The GIWAXS experiments were conducted on the NCD-SWEET beamline of the ALBA synchrotron, Spain. GIWAXS experiments of Ni(HITP) and COF-TAPB-BTCA were performed at the NCD-SWEET beamline at ALBA Synchrotron with the collaboration of ALBA staff.To date, crystallization studies conducted in space laboratories, which are prohibitively costly and unsuitable to most research laboratories, have shown the valuable effects of microgravity during crystal growth and morphogenesis. Herein, an easy and highly efficient method is shown to achieve space-like experimentation conditions on Earth employing custom-made microfluidic devices to fabricate 2D porous crystalline molecular frameworks. It is confirmed that experimentation under these simulated microgravity conditions has unprecedented effects on the orientation, compactness and crack-free generation of 2D porous crystalline molecular frameworks as well as in their integration and crystal morphogenesis. It is believed that this work will provide a new "playground" to chemists, physicists, and materials scientists that desire to process unprecedented 2D functional materials and devices

    Setting the scene and generating evidence for malaria elimination in Southern Mozambique

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    Mozambique has historically been one of the countries with the highest malaria burden in the world. Starting in the 1960s, malaria control efforts were intensified in the southern region of the country, especially in Maputo city and Maputo province, to aid regional initiatives aimed to eliminate malaria in South Africa and eSwatini. Despite significant reductions in malaria prevalence, elimination was never achieved. Following the World Health Organization's renewed vision of a malaria-free-world, and considering the achievements from the past, the Mozambican National Malaria Control Programme (NMCP) embarked on the development and implementation of a strategic plan to accelerate from malaria control to malaria elimination in southern Mozambique. An initial partnership, supported by the Bill and Melinda Gates Foundation and the La Caixa Foundation, led to the creation of the Mozambican Alliance Towards the Elimination of Malaria (MALTEM) and the Malaria Technical and Advisory Committee (MTAC) to promote national ownership and partner coordination to work towards the goal of malaria elimination in local and cross-border initiatives. Surveillance systems to generate epidemiological and entomological intelligence to inform the malaria control strategies were strengthened, and an impact and feasibility assessment of various interventions aimed to interrupt malaria transmission were conducted in Magude district (Maputo Province) through the "Magude Project". The primary aim of this project was to generate evidence to inform malaria elimination strategies for southern Mozambique. The goal of malaria elimination in areas of low transmission intensity is now included in the national malaria strategic plan for 2017-22 and the NMCP and its partners have started to work towards this goal while evidence continues to be generated to move the national elimination agenda forward

    Ciencia en Sociedad. Reflexiones en el marco de su relación bidireccional

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    Con autorización de la editorial para este libro. La edición de este libro estuvo a cargo de Jesús Rey Rocha y Víctor Ladero.Este libro surge como una iniciativa para compilar una serie de artículos alumbrados a partir de la génesis del Grupo CURIE (Científic@s Unid@s por la Reactivación de la Investigación en España), semilla de la Asociación Española para el Avance de la Ciencia (AEAC). Durante meses sus miembros estuvieron intercambiando reflexiones y debatiendo sobre la distancia entre la ciencia y la sociedad, y la necesidad de crear una asociación que llenase ese vacío entre los científicos y los ciudadanos, que apostase por llevar la ciencia y los conocimientos generados por la misma a toda la sociedad, tal y como establecen la Declaración de Derechos Humanos y la Constitución Española, en su artículo 44.Peer reviewe
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